1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)

Toll-like Receptor (TLR)

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system。 They are single, membrane-spanning, non-catalytic receptors usually expressed in sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes。 Once these microbes have breached physical barriers such as the skin or intestinal tract mucosa, they are recognized by TLRs, which activate immune cell responses。 The TLRs include TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13。 Toll-Like Receptors (TLRs) play a critical role in the early innate immune response to invading pathogens by sensing microorganism and are involved in sensing endogenous danger signals。 TLRs are evolutionarily conserved receptors are homologues of the Drosophila Toll protein, discovered to be important for defense against microbial infection。 TLRs recognize highly conserved structural motifs known as pathogen-associated microbial patterns (PAMPs), which are exclusively expressed by microbial pathogens。

Toll-like Receptor (TLR) 相关产品 (32):

Cat. No. Product Name Effect Purity
  • HY-11109
    Resatorvid Inhibitor 99.95%
    Resatorvid (TAK-242) 是一种有效的 TLR4 信号传导抑制剂,可选择性地抑制TLR-介导的细胞因子和一氧化氮的产生。
  • HY-17589
    Chloroquine diphosphate Inhibitor 99.94%
    Chloroquine diphosphate是一种广泛用于治疗疟疾和类风湿性关节炎的抗疟疾和抗炎药。 Chloroquine 是 autophagytoll-like receptors (TLRs) 的抑制剂。
  • HY-13740
    Resiquimod Agonist 99.82%
    Resiquimod是一种Toll样受体7和8 (TLR7/TLR8) 的激动剂, 诱导细胞因子如TNF-α,IL-6和IFN-α的上调。
  • HY-100461
    C29 Inhibitor >98.0%
    C29是Toll样受体2 (Toll-like receptor 2 (TLR2)) 抑制剂。
  • HY-B1370
    Hydroxychloroquine sulfate Inhibitor 99.99%
    Hydroxychloroquine sulfate 是一种合成的抗疟疾药物,也可以抑制 Toll 样受体 7/9 (TLR7/9) 信号传导。
  • HY-111358
    TLR 7 agonist 1 Agonist
    TLR 7 agonist 1是有效,选择性,可口服的 TLR7 激动剂,IC50为 90 nM。
  • HY-112146
    MMG-11 Antagonist
    MMG-11 是一种有效的选择性人 TLR2 拮抗剂。MMG-11 抑制 TLR2/1 和 TLR2/6 信号转导,抑制 Pam3CSK4 诱导的 hTLR2/1,IC50 为 1.7 μM,抑制 Pam2CSK4 诱导的 hTLR2/6 反应,IC50 为 5.7 μM。
  • HY-125171
    IAXO-102 Antagonist
    IAXO-102 是 TLR4 的拮抗剂,抑制 MAPK 和 p65 NF-kB 的磷酸化,这些与 TLR4 和 TLR4 依赖性的炎性蛋白的表达下调有关。IAXO-102 抑制实验性腹主动脉瘤的发展。
  • HY-B0180
    Imiquimod Agonist 99.37%
    1-NM-PP1是可渗透细胞和突变选择性的 CDK 抑制剂。
  • HY-15601
    Vesatolimod Agonist 98.78%
    Vesatolimod (GS-9620) 是一种有效,选择性,可口服的 Toll 样受体7 (TLR7) 激动剂,EC50 值为291 nM。
  • HY-13773
    Motolimod Agonist 98.83%
    Motolimod 是选择性的Toll样受体 8 (TLR8) 激动剂,EC50约为 100 nM。
  • HY-108471
    CU CPT 22 Inhibitor >99.0%
    CU CPT 22 是一种 toll 样受体 1 和 2 (TLR1/2) 抑制剂, 其 IC50 值为 0.58 μM。
  • HY-12756A
    E6446 dihydrochloride Antagonist 99.96%
    E6446 dihydrochloride 是一种有效的、可口服的 TLR7TLR9 拮抗剂,可用于有害炎症反应的研究。
  • HY-N0201
    Atractylenolide I Antagonist 99.08%
    Atractylenolide I 是从白术根中得到的倍半萜烯,具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。Atractylenolide I 为 TLR4 的拮抗剂,同时在 A375 细胞中,能够降低 JAK2STAT3 的磷酸化水平。
  • HY-100442
    Paquinimod 98.38%
    Paquinimod 是一种 S100A9 抑制剂,阻止 S100A9 与 TLR-4 结合。
  • HY-103698A
    TLR7/8 agonist 1 dihydrochloride Agonist 98.02%
    TLR7/8 agonist 1 dihydrochloride 是一种 toll 样受体 (TLR7)/TLR8 的双重激动剂。
  • HY-101929
    CU-CPT17e Agonist 98.02%
    CU-CPT17e 是一种多 Toll 样受体 (TLR) 激动剂,可激活 TLR3TLR8TLR9
  • HY-103697A
    Gardiquimod trifluoroacetate Agonist 99.28%
    Gardiquimod trifluoroacetate 是一个特异的 TLR7 激动剂,也能抑制 HIV-1 逆转录酶。
  • HY-N0795
    Procyanidin B1 Antagonist 99.92%
    Procyanidin B1 是一种多酚类黄酮物质,存在于常见的水果中,能够与 TLR4/MD-2 复合体结合,具有抗炎活性。
  • HY-10018
    Toll-like receptor modulator Modulator 99.40%
    Toll-like receptor modulator 是一种 TLR7/8 调节剂,能够调节免疫功能。
Isoform Specific Products

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