1. Membrane Transporter/Ion Channel
  2. TRP Channel

TRP Channel

TRP Channel (Transient receptor potential channel) is a group of ion channels located mostly on the plasma membrane of numerous human and animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA. In group 2, there are TRPP ("P" for polycystic) and TRPML ("ML" for mucolipin). Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRP channels are relatively non-selectively permeable to cations, including sodium, calcium and magnesium. TRP channels are initially discovered in trp-mutant strain of the fruit fly Drosophila. Later, TRP channels are found in vertebrates where they are ubiquitously expressed in many cell types and tissues. TRP channels are important for human health as mutations in at least four TRP channels underlie disease.

TRP Channel 相关产品 (63):

Cat. No. Product Name Effect Purity
  • HY-17386
    Rosiglitazone Modulator 99.21%
    Rosiglitazone (BRL49653) 是一种选择性的PPARγ 激动剂,对 PPARγ1PPARγ2PPARγEC50 分别为 30 nM,100 nM 和 60 nM。
  • HY-10448
    Capsaicin Agonist 98.39%
    Capsaicin是一种 TRPV1 激动剂,在HEK293细胞中的 EC50 为0.29 μM。
  • HY-15640
    Capsazepine Antagonist >99.0%
    Capsazepine是感觉神经元兴奋毒素的合成类似物,和TRPV1 受体拮抗剂,其中IC50 为562 nM。
  • HY-101840
    EIPA Inhibitor 99.73%
    EIPA 是一种 TRPP3 channel 抑制剂,其 IC50 值为 10.5 μM。EIPA 还抑制 Na+/H+ 交换器 (NHE) 和巨噬细胞的增多。
  • HY-100965
    Diphenyleneiodonium chloride Activator 99.87%
    Diphenyleneiodonium chloride 是一种 NADPH 氧化酶 (NOX) 抑制剂,也是一种 TRPA1 激活剂,EC50 值在 1 至 3 μM 之间。
  • HY-112430
    TRPM8 Antagonist Antagonist 98.20%
    TRPM8 Antagonist 是一种有效的,选择性的 TRPM8 拮抗剂,IC50 值为 0.2 nM,可用于研究神经性疼痛综合症。
  • HY-75161
    (-)-Menthol Activator >98.0%
    (-)-Menthol 是薄荷油的关键成分,(-)-Menthol 结合并激活瞬瞬时受体电位 M8 (TRPM8),TRPM8 是 Ca2+-可渗透的非选择性阳离子通道,最终增加 [Ca2+]i。 具有抗肿瘤活性。
  • HY-112298
    DS88790512 Inhibitor
    DS88790512是有效,选择性,有口服活性的 TRPC6 抑制剂,IC50为 11 nM。
  • HY-15064
    HC-030031 Inhibitor 98.01%
    HC-030031 是一种有效的选择性的 TRPA1 抑制剂,拮抗 AITC 和福尔马林诱发的钙流入,IC50 分别为 6.2±0.2 和 5.3±0.2 μM。
  • HY-100001
    SKF-96365 hydrochloride Inhibitor 99.44%
    SKF-96365 hydrochloride 是非选择性的TRP通道抑制剂。
  • HY-B0545
    Probenecid Agonist 99.91%
    Probenecid 是一种有效的选择性瞬时受体电位香草酸受体通道 2 (TRPV2) 激动剂。
  • HY-100208
    HC-067047 Antagonist >98.0%
    HC-067047是一种有效,选择性的 TRPV4 拮抗剂,抑制人,大鼠,小鼠TRPV4的IC50 分别为48 nM,133 nM,17 nM。
  • HY-101736
    AMG9810 Antagonist 99.42%
    AMG9810是选择性和竞争性的香草素受体1 (TRPV1) 拮抗剂,对人类和大鼠TRPV1的IC50值分别为24.5 和 85.6 nM。
  • HY-19608
    GSK1016790A Agonist
    GSK1016790A是有效的瞬时受体电位香草酸4 (TRPV4) 激活剂。
  • HY-15699
    SAR7334 Inhibitor 99.91%
    SAR7334是TRCP6新型高效抑制剂,摘自专利WO 2011107474 A1 20110909(Example3)。
  • HY-18779
    PF-4840154 Agonist 99.59%
    PF-4840154是有效,选择性的大鼠和人 TrpA1 通道激动剂, EC50分别为97和23nM。
  • HY-19975
    RN-1734 Antagonist 99.01%
    RN-1734是一种选择性TRPV4通道拮抗剂, 完全拮抗4αPDD介导的TRPV4活化, 作用于hTRPV4, mTRPV4, 和rTRPV4, IC50分别为 2.3 μM, 5.9 μM, 3.2 μM。
  • HY-15699A
    SAR7334 hydrochloride Inhibitor
    SAR7334 hydrochloride 是一种有效的 TRPC6 特异性抑制剂,能够抑制 TRPC6 电流,IC50 值为 7.9 nM。
  • HY-10634
    AMG 517 Antagonist 99.87%
    AMG 517是有效的香草素受体-1 (TRPV1) 拮抗剂,IC50值为0.5 nM。
  • HY-18662
    RQ-00203078 Antagonist 99.35%
    RQ-00203078是一种口服有效的, 高度选择性TRPM8拮抗剂,作用于鼠和人离子通道, IC50 值分别为5.3 和 8.3 nM。
Isoform Specific Products

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Please try each isoform separately。

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