1. PI3K/Akt/mTOR
  2. PTEN

PTEN

PTEN (Phosphatase and tensin homologue deleted on chromosome 10), a phosphoinositide 3-phosphatase, is an important regulator of insulin-dependent signaling. The loss or impairment of PTEN results in an antidiabetic impact, which led to the suggestion that PTEN could be an important target for drugs against type II diabetes. PTEN has a much wider active site cleft enabling it to bind the PtdIns(3,4,5)P3 substrate. a highly potent and specific inhibitor of PTEN that increases cellular PtdIns(3,4,5)P3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations.

PTEN 相关产品 (3):

Cat. No. Product Name Effect Purity
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

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