1. Immunology/Inflammation
  2. MyD88


MyD88 (Myeloid differentiation primary response gene 88) is a protein that, in humans, is encoded by the MYD88 gene。 Available evidence suggests that MYD88 is dispensable for human resistance to common viral infections and to all but a few pyogenic bacterial infections, demonstrating a major difference between mouse and human immune responses。 MyD88 is an essential adaptor protein in the IL-1R1 signaling pathway。 MyD88 may define a family of signal transduction molecules with an ancestral function in the activation of the immune system。 MyD88 functions as a pure adaptor linking the IL-1R1 to downstream IRAK kinases。 Mutation in MYD88 at position 265 leading to a change from leucine to proline have been identified in many human lymphomas including ABC subtype of Diffuse Large B-cell Lymphoma and Waldenstrom's Macroglobulinemia。

MyD88 相关产品 (1):

Cat. No. Product Name Effect Purity
  • HY-50937
    ST 2825 Inhibitor 99.51%
    ST 2825 是一种 MyD88 二聚化抑制剂。
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