1. Protein Tyrosine Kinase/RTK
  2. DYRK


Mammalian DYRKs are a subfamily of mitogen-activated protein kinase-related protein kinases and are originally discovered on the basis of homology to the Saccharomyces cerevisiae Yak1 and Drosophila mini-brain kinases. DYRKs possess Ser/Thr phosphorylation activity as well as autophosphorylation activity on Tyr residue(s).

Two isoforms of DYRK, DYRK1A and DYRK1B, co-immunoprecipitate with HAN11 when coexpressed in COS cells indicating that the proteins interact in mammalian cells。 Co-expression of DYRK1A, DYRK1B, or DYRK2 with a series of glycogen synthase mutants with Ser/Ala substitutions at the phosphorylation sites in COS cells revealed that protein kinases cause phosphorylation of site 3a in glycogen synthase。 Control of glycogen synthase by DYRK represents a novel mechanism, and a potentially novel pathway, for the regulation of glycogen synthesis。

DYRK 相关产品 (7):

Cat. No. Product Name Effect Purity
  • HY-N0737A
    Harmine Inhibitor 99.78%
    Harmine是一种具有抗癌和抗炎活性的天然双特异性酪氨酸磷酸化调节激酶 ((DYRK)) 抑制剂。
  • HY-12277
    AZ191 Inhibitor 99.63%
  • HY-12838
    Mirk-IN-1 Inhibitor 99.53%
  • HY-15838
    ID-8 Inhibitor >98.0%
  • HY-U00439A
    Protein kinase inhibitors 1 hydrochloride Inhibitor >98.0%
    Protein kinase inhibitors 1 hydrochloride 是一种有效的 HIPK2 抑制剂,对 HIPK1 和 HIPK2 的 IC50 值分别为 136 和 74 nM,对 HIPK2 的 Kd 值为 9.5 nM。
  • HY-U00439
    Protein kinase inhibitors 1 Inhibitor >99.0%
    Protein kinase inhibitors 1 是一个新型的 HIPK2 抑制剂,其 IC50 值为 74 nM, Kd 值为 9.5 nM。
  • HY-111380
    EHT 5372 Inhibitor
    EHT 5372 是双特异性酪氨酸磷酸化调节酶 (DYRK) 的强效抑制剂,其 IC50 值分别为 0.22,0.28 nM。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

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