1. Membrane Transporter/Ion Channel
  2. Chloride Channel

Chloride Channel

Chloride channels represent a relatively under-explored target class for drug discovery as elucidation of their identity and physiological roles has lagged behind that of many other drug targets. Chloride channels are involved in a wide range of biological functions, including epithelial fluid secretion, cell-volume regulation, neuroexcitation, smooth-muscle contraction and acidification of intracellular organelles. Mutations in several chloride channels cause human diseases, including cystic fibrosis, macular degeneration, myotonia, kidney stones, renal salt wasting and hyperekplexia. Chloride-channel modulators have potential applications in the treatment of some of these disorders, as well as in secretory diarrhoeas, polycystic kidney disease, osteoporosis and hypertension.

Chloride channel accessory proteins, also known as calcium-activated chloride channel regulators (CLCA proteins), are a family of transmembrane proteins that have been suggested to have a role in chloride conductance in epithelial cells。

Chloride Channel 相关产品 (13):

Cat. No. Product Name Effect Purity
  • HY-N0822
    Shikonin Inhibitor 99.80%
    Shikonin是中草药紫草的主要成分。 Shikonin显示出各种生物活性,包括抑制TNF-αNF-κBHIV-1
  • HY-12693
    R(+)-IAA-94 Inhibitor 98.37%
  • HY-B1221
    Flufenamic acid Inhibitor 99.92%
    Flufenamic acid 是一种非甾体类抗炎剂,能够抑制 COX 的活性,激活 AMPK 的活性,调节离子通道,阻滞氯离子通道 (chloride channel) 和 L-型钙离子通道 (L-type Ca2+ channel),调节非选择性阳离子通道,激活钾离子通道 (K+ channel) 等。
  • HY-100611
    CaCCinh-A01 Inhibitor 99.60%
    CaCCinh-A01 是 TMEM16A 和钙激活氯化物通道 (CaCC) 的抑制剂,IC50 值分别为 2.1 和 10 μM。
  • HY-B0679
    Lubiprostone Activator >98.0%
  • HY-101012
    NPPB Inhibitor 99.89%
    NPPB 是外向整流氯化物通道 (ORCC) 的阻断剂。
  • HY-108690
    Fluxametamide Antagonist 98.51%
    Fluxametamide 是一种广谱的杀虫剂,为 GABA-和谷氨酸门控氯离子通道 (chloride channel) 拮抗剂,对 M. domestica 中 GABACl 和 GluCl 的 IC50 值分别为 1.95  nM 和 225  nM。
  • HY-B0493
    Niflumic acid Inhibitor 99.86%
    Niflumic acid是钙离子激活的氯离子通道阻断剂,可作用于风湿性关节炎。
  • HY-18996
    Adjudin Inhibitor >98.0%
    Adjudin 是一种广泛研究的男性避孕试剂,具有优越的线粒体抑制作用。 Adjudin 也是一种有效的 Cl- 通道阻断剂。
  • HY-P0173A
    Chlorotoxin Inhibitor >98.0%
    Chlorotoxin是从雷蛇属以色列蝎子的毒液中提取的由36个氨基酸组成的肽段,具有抗癌活性。Chlorotoxin是氯离子通道 (chloride channel) 阻断剂。
  • HY-B0908
    Meticrane Inhibitor 98.79%
    Meticrane 是一种利尿剂。Meticrane 抑制远曲小管中钠离子和氯离子的重吸收。Meticrane 可于治疗原发性高血压。
  • HY-100244
    NS1652 Inhibitor
    NS1652 是一种可逆的阴离子电导 (anion conductance) 抑制剂,在人和小鼠的红细胞中,可以抑制氯离子通道 (chloride channel),IC50 值为 1.6 μM。
  • HY-100322
    H100 Inhibitor
    H100 是一种氯离子运输 (Cl- transport) 抑制剂,可以部分抑制氯离子载体 NaK2Cl cotransporter 和 Band 3 anion exchanger,但是对 KCl cotransporter 无作用。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

北京赛车高倍率平台 北京赛车营业时间 秒速时时彩计划 秒速时时彩计划 秒速时时彩官网 北京赛车高倍率平台 秒速时时彩网址 秒速时时彩 秒速时时彩计划 北京赛车高倍率平台