1. Membrane Transporter/Ion Channel
  2. CRAC Channel

CRAC Channel

The Ca2+ release-activated Ca2+ (CRAC) channel is a highly Ca2+-selective store-operated channel expressed in T cells, mast cells, and various other tissues. CRAC channels regulate critical cellular processes such as gene expression, motility, and the secretion of inflammatory mediators. The identification of Orai1, a key subunit of the CRAC channel pore, and STIM1, the endoplasmic reticulum (ER) Ca2+ sensor, have provided the tools to illuminate the mechanisms of regulation and the pore properties of CRAC channels. Opening of CRAC channels enables the refilling of ER Ca2+ stores and sustains long-lasting Ca2+ oscillations and plateau signals, critical for the proliferation of T cells and production of cytokines following antigenic stimulation.

CRAC Channel 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-100831
    YM-58483 Inhibitor 98.31%
    YM-58483 是一种有效的 CRAC channels 抑制剂,能够抑制 Ca2+ 信号。
  • HY-101942
    CM-4620 Inhibitor 99.94%
    CM-4620 是钙离子释放激活通道 (CRAC channel) 的抑制剂,其对 Orai1/STIM1 和 Orai2/STIM1 的 IC50 值分别为 119 nM, 895 nM。
  • HY-111325
    Synta66 Inhibitor 99.31%
    Synta66 是钙离子通道 Orai (CRAC 的核心) 的抑制剂,主要用于神经疾病的研究。
  • HY-12521
    GSK-5498A Inhibitor
    GSK-5498A 是CARC离子通道选择性小分子抑制剂(IC50 = 1_mu_M);抑制肥大细胞介质释放和T细胞促炎性细胞因子的释放。
  • HY-20588
    CRAC intermediate 2 Inhibitor 99.96%
    CRAC intermediate 2是摘自专利WO 2013059666A1中用于CRAC系列抑制剂合成的中间体。
  • HY-20587
    CRAC intermediate 1 Inhibitor
    CRAC intermediate 1是从专利WO 2010122089摘取出的关键中间体,用于CRAC离子通道系列化合物的合成。
Isoform Specific Products

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