1. Metabolic Enzyme/Protease
  2. ATGL

ATGL

Adipose triglyceride lipase (ATGL) is rate-limiting in the mobilization of fatty acids from cellular triglyceride stores. This central role in lipolysis marks ATGL as interesting pharmacological target since deregulated fatty acid metabolism is closely linked to dyslipidemic and metabolic disorders. Here we report on the development and characterization of a small-molecule inhibitor of ATGL. Atglistatin is selective for ATGL and reduces fatty acid mobilization in vitro and in vivo. ATGL performs the first step in triacylglycerol (TG) catabolism generating diacylglycerol which is subsequently degraded by hormone-sensitive lipase (HSL) and monoglyceride lipase (MGL) into glycerol and fatty acids (FA).

Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are the major enzymes contributing to triacylglycerol (TG) breakdown in in vitro assays and in organ cultures of murine white adipose tissue (WAT)。

ATGL 相关产品 (1):

Cat. No. Product Name Effect Purity
  • HY-15859
    Atglistatin Inhibitor 98.06%
    Atglistatin 是一种选择性的脂肪甘油三酯脂酶 (ATGL) 抑制剂,体外抑制脂解作用,IC50 为 0.7 μM。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

秒速时时彩 北京赛车营业时间 秒速时时彩开奖记录数据分析 秒速时时彩开奖 北京赛车时间表 秒速时时彩网址 北京赛车高倍率平台 秒速时时彩开奖记录数据分析 秒速时时彩开奖网 秒速时时彩官网