JNJ-38877605 

目录号: HY-50683 纯度: 99。95%
产品使用指南

JNJ-38877605是ATP竞争性c-Met抑制剂,IC50为4 nM,对c-Met的抑制性比对其它200种酪氨酸和丝氨酸-苏氨酸激酶的抑制性要强600倍。

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JNJ-38877605 Chemical Structure

JNJ-38877605 Chemical Structure

CAS No. : 943540-75-8

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥1155 In-stock
5 mg ¥1050 In-stock
10 mg ¥1841 In-stock
50 mg ¥5115 In-stock
100 mg ¥10025 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases. IC50 value: 4 nM [1] Target: c-Met in vitro: JNJ-38877605 shows more than 600-fold selectivity for c-Met compared with more than 200 other diverse tyrosine and serine-threonine kinases and also potently inhibits HGF-stimulated and constitutively activated c-Met phosphorylation in vitro. [1] In EBC1, GTL16, NCI-H1993, and MKN45 cells, JNJ-38877605 (500 nM) leads to a significant reduction of phosphorylation of Met and RON, another key player in invasive growth [2]. A recent study shows that JNJ-38877605 is involved in modulating secretion of IL-8, GROa, uPAR and IL-6 in GTL16 cells [3]. in vivo: In mice bearing established GTL16 xenografts, JNJ-38877605, dosed orally with 40 mg/kg/day for 72 hours, results in a statistically significant decrease in the plasma levels of human IL-8 (from 0.150 ng/mL to 0.050 ng/mL) and GROα (from 0.080 ng/mL to 0.030 ng/mL). While concentrations of uPAR in the blood become reduced to more than 50% at the same dose [3].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (79.50 mM)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6501 mL 13.2503 mL 26.5006 mL
5 mM 0.5300 mL 2.6501 mL 5.3001 mL
10 mM 0.2650 mL 1.3250 mL 2.6501 mL
*Please refer to the solubility information to select the appropriate solvent。
References
  • [1].

    [2].

    [3].

Molecular Weight

377.35

Formula

C₁₉H₁₃F₂N₇

CAS No.

943540-75-8

SMILES

FC(F)(C1=NN=C2C=CC(C3=CN(C)N=C3)=NN21)C4=CC5=C(N=CC=C5)C=C4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.95%

  • [1]。

    [2].

    [3].

  • 摩尔计算器

  • 稀释计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
JNJ-38877605
目录号:
HY-50683
需求量:

JNJ-38877605

Cat. No.: HY-50683

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